Bringing together scientists from diverse biological disciplines, the International Society of Protein Termini (ISPT) unites researchers interested in the structure, substrates, and regulatory roles of protein termini across prokaryotic, animal, and plant systems. This community converges to explore enzymatic modifications, cellular quality control mechanisms, and their implications for organelle dynamics and stress responses. Advances in terminomics, cryo-EM studies, and biotechnological applications such as PROTACs underscore the field’s transformative potential in medical sciences and biotechnology.