Since 2017, the International Society for Protein Termini (ISPT) has built a thriving global community and hosted biennial meetings in Halle, Seoul, Bergen (EMBO-funded), and Oxford (FEBS-funded). These meetings have provided a unique platform for innovation, connecting senior leaders and early-career scientists while fostering collaborations across disciplines. The 2026 workshop in Palermo will build on this strong foundation to deliver the only international platform fully dedicated to protein termini.
ISPT Meeting 2024 in Oxford
Protein Termini 2024: from insight to impact
8-11 September 2024
Oxford, UK
FEBS Workshop
The past decade has seen a broad increase in the understanding that protein function is regulated by co- and post-translational modification of their N- and C-termini. Active research in this field is expanding, including in mechanistic understanding of protein modification, in technologies for examining protein termini and in identification of routes by which protein terminal modifications can be exploited for beneficial purposes. This FEBS Workshop will bring together established expertise in the field with new contributors, and will highlight the opportunities to capitalize on knowledge of protein termini for translation into novel methodologies, therapeutics and agri-tech solutions. Session topics will include ‘Structural and biochemical characterization of protein termini’, ‘New insights into N-terminal processing’, ‘Protein C-termini’, ‘Advances in methodology’, ‘Physiological impact of protein terminal modification’ and ‘Exploiting protein termini’.
ISPT Meeting 2022 in Bergen
Protein termini: From mechanisms to biological impact
8-11 June 2022
Bergen, Norway
EMBO Workshop
The overarching theme of this workshop is the termini of proteins and their major roles in proteostasis and as biological regulators. The N-terminus of a protein is the first to encounter the cellular environment and represents the first opportunity for the cell to steer a protein. During protease action, neo N- and C-termini are generated and further opens up for terminal-directed regulation.
This conference will bring together scientists and students working on the co- and post-translational regulation of proteins, terminal protein modifications and modifying enzymes, and the impact of such terminal modifications at the protein level as well as in a broader biological perspective including human disease and plant homeostasis. The event will be relevant for researchers in the fields of structural biology, biochemistry, molecular biology, cell biology, systems biology and biomedicine, and encompass model systems and biological regulation in bacteria, yeast, mammals and plants.
The main objective will be to explore the molecular mechanisms, concepts and impact of protein regulation via its termini in order to generate new knowledge and synergistic research efforts.
Topics covered will include:
Ribosomes and the nascent chain
Structural biology of the ribosome, ribosome associated factors and enzymes acting on protein termini
N-terminal and C-terminal protein modifications, including acetylation, myristoylation, formylation, methylation, and arginylation
N-terminal methionine excision pathway
N-degron and C-degron pathways of protein degradation
Oxygen sensing in animals and plants
Protein folding
Drug targeting
ISPT Meeting 2019 in Seoul
„Protein Termini 2019“
4-5 October 2019
Seoul National University (SNU) in Seoul, Korea
Over the past decades, research on protein termini has been continuously expanding in its components, mechanisms, and functions, now drawing attention from people in otherwise different fields. Scientists working on protein termini, including those on the N-end rule pathway, gradually realized that we need a network and society, where we belong to and wherein we exchange ideas and feel our own identifies among the fields of biological sciences. In 2017, a group of people in Europe held the „N-term 2017 – Proteostasis via the N-terminus“ (nterm2017.org) conference at Halle, Germany, the first international interdisciplinary meeting g on protein N-termini. In 2018, we founded the International Society of Protein Termini (ISPT), a non-profit organization (ispt.world), to gather together researchers in the fields of the N-end rule pathway as well as all aspects of protein termini and related fields. These include the role of protein termini in proteolysis via the ubiquitin-proteasome and the autophagy-lysosome systems. Approximately 300 people including ~100 PIs are expected to join ISPT.
„Protein Termini 2019“ is a continuation of our recent efforts to form a society of protein termini.
For updates, please follow @proteintermini, the official Twitter account of the ISPT. When tweeting, please use #proteintermini2019 and also have a look at #nterm2019
Seoul National University, Medical School
ISPT Meeting 2017 in Halle
